The Sokollu Mehmed Pasha Mosque (Turkish: Sokollu Mehmet Paşa Camii) is a 16th-century Ottoman mosque located in Istanbul, Turkey.

The mosque is situated in Azapkapı neighborhood of Beyoğlu district in Istanbul. It is directly beside the Atatürk Bridge across the Golden Horn, but there was no bridge here at the time the mosque was built. It was designed by Ottoman imperial architect Mimar Sinan (c. 1488/1490-1588) and built for the grand vizier Sokollu Mehmed Pasha (in office 1565–1579) in 1578.

 It is one of the three mosques with the same name built by Mimar Sinan in Istanbul.